TT-10 |CAS:2230640-94-3 Probechem Biochemicals

Chemical Structure : TT-10

CAS No.: 2230640-94-3

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TT-10 (YAP-TEAD activator TT-10, TAZ-K)

货号: PC-35820Not For Human Use, Lab Use Only.

TT-10 (YAP-TEAD activator TT-10) is a small molecule activator that activates pro-proliferative YES-associated protein (YAP) and transcriptional enhancer factor domain (TEAD) activities in cardiomyocytes.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4780	In stock
100 mg		Get quote

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生物&药学活性

TT-10 (YAP-TEAD activator TT-10) is a small molecule activator that activates pro-proliferative YES-associated protein (YAP) and transcriptional enhancer factor domain (TEAD) activities in cardiomyocytes.
TT-10 promotes cardiomyocyte proliferation and simultaneously exerts antioxidant and antiapoptotic effects in vitro via nuclear translocation of YAP, activates YAP-TEADs activity and the Wnt/β-Catenin signaling pathway.
TT-10 ameliorates cardiac dysfunction, decreases ROS and DNA aamage and apoptosis after myocardial infarction (MI) in mice.

物理化学性质&存储条件

分子量	283.339
分子式	C11H10FN3OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-(allylamino)-4-aminothiazol-5-yl)(5-fluorothiophen-2-yl)methanone

参考文献

1. Hara H, et al. JACC Basic Transl Sci. 2018 Nov 12;3(5):639-653.

TT-10 (YAP-TEAD activator TT-10, TAZ-K)

生物&药学活性

物理化学性质&存储条件

参考文献

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TT-10 (YAP-TEAD activator TT-10, TAZ-K)

生物&药学活性

物理化学性质&存储条件

参考文献

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