TSWV inhibitor Z9

Chemical Structure : TSWV inhibitor Z9

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货号: PC-24208Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

TSWV inhibitor Z9 is a small molecule inhibitor of tomato spotted wilt virus (TSWV) nucleocapsid protein (N), targets N protein (KD=7.6 uM) to inhibit the replication level of the viral ribonucleoprotein (RNP).
Z9 is a compound with broad-spectrum antiviral activity against plant viruses. decreases N protein condensation in plant cells.
Z9 significantly disrupts the formation of inclusion bodies (IBs).
Z9 is capable of interacting with the amino acids in the nucleic acid binding region of TSWV N, disrupting the assembly of N and RNA into phase-separated condensates, the reduction of which is detrimental to the stability of the N protein.

物理化学性质&存储条件

分子量	445.60
分子式	C22H27N3O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(dimethylamino)propyl (E)-4-(3-(4-oxo-4H-chromen-3-yl)acryloyl)piperazine-1-carbodithioate

参考文献

1. Zan N, et al. Nat Commun. 2025 Feb 27;16(1):2034.