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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-TST1N-224
TST1N-224

Chemical Structure : TST1N-224

CAS No.: 50566-97-7

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TST1N-224

货号: PC-22813Not For Human Use, Lab Use Only.

TST1N-224 is a potent inhibitor targeting the response regulator VraRC of S. aureus, inhibits the formation of the VraRC-DNA complex with IC50 of 60.2 uM, shows strong binding to VraRC (KD=23.4 uM), enhances the susceptibility of vancomycin-intermediate S. aureus (VISA) to both vancomycin and methicillin.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TST1N-224 is a potent inhibitor targeting the response regulator VraRC of S. aureus, inhibits the formation of the VraRC-DNA complex with IC50 of 60.2 uM, shows strong binding to VraRC (KD=23.4 uM), enhances the susceptibility of vancomycin-intermediate S. aureus (VISA) to both vancomycin and methicillin.

物理化学性质&存储条件

分子量 460.62
分子式 C10H20O8S6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,2'-(((1,2,5,6-tetrathiocane-3,8-diyl)bis(methylene))bis(oxy))bis(ethane-1-sulfonic acid)

参考文献

1. Ying-Chu Hsu, et al. J Chem Inf Model. 2024 Jul 30. doi: 10.1021/acs.jcim.4c01046.

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