TSPO agonist CB34 | TSPO agonist | Probechem Biochemicals

Chemical Structure : TSPO agonist CB34

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TSPO agonist CB34 (CB34)

货号: PC-60733Not For Human Use, Lab Use Only.

TSPO agonist CB34 is a potent, selective translocator protein 18 kDa (TSPO/PBR) agonist with IC50 of 2.59 and 1.03 nM in competing with [3H]-PK11195 for binding to membrane preparations from rat cerebral cortex and ovary, respectively.

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生物&药学活性

TSPO agonist CB34 is a potent, selective translocator protein 18 kDa (TSPO/PBR) agonist with IC50 of 2.59 and 1.03 nM in competing with [3H]-PK11195 for binding to membrane preparations from rat cerebral cortex and ovary, respectively.
TSPO agonist CB34 does not show any affinity for central benzodiazepine receptors, has little or no marked effects on GABA-evoked Cl- currents.
TSPO agonist CB34 induces a dose-dependent increase in the concentrations of neuroactive steroids in plasma and brain, stimulate brain steroidogenesis in vivo.

物理化学性质&存储条件

分子量	438.777
分子式	C21H22Cl3N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N-Dipropyl-2-(4-chlorophenyl)-6,8-dichloro-imidazo[1,2-a]pyridine-3-acetamide

参考文献

1. Serra M, et al. Br J Pharmacol. 1999 May;127(1):177-87.

2. Mitsui K, et al. Neuropharmacology. 2015 Dec;99:51-66.

TSPO agonist CB34 (CB34)

生物&药学活性

物理化学性质&存储条件

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TSPO agonist CB34 (CB34)

生物&药学活性

物理化学性质&存储条件

参考文献

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