TS-002266 (TS002266)

Chemical Structure : TS-002266

加入收藏

货号: PC-27674Not For Human Use, Lab Use Only.

TS-002266 is a potent and selective RNA terminal uridylyl transferase enzymes 4 and 7 (TUT4/7) inhibitor, blocks miRNA uridylation in vitro with biochemical IC50 of 69 and 16 nM for TUT4 and TUT7, respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

TS-002266 is a potent and selective RNA terminal uridylyl transferase enzymes 4 and 7 (TUT4/7) inhibitor, blocks miRNA uridylation in vitro with biochemical IC50 of 69 and 16 nM for TUT4 and TUT7, respectively.
TS-002266 substantially reduces uridylation and demonstrate in vitro and in vivo antiproliferative activity specifically in FOCAD-deleted cancer.
TS-002266 significantly decreases the proliferation and colony formation of human NOMO-1 cells.
TS-002266 sensitizes AML cells to venetoclax in a variety of blood cancers.
TS-002266 reduces their proliferation and induces apoptosis in murine Meis1/Hoxa9 transformed cells.
TS-002266 exhibits reduced colony formation capacity in primary AML patient samples.

物理化学性质&存储条件

分子量	639.53
分子式	C31H32Cl2N6O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-6-Chloro-7-(2-(((3-chloro-4-methoxypyridin-2-yl)oxy)methyl)pyrrolidin-1-yl)-1-(6-(3-(dimethylamino)azetidin-1-yl)pyridin-3-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

参考文献

1. Triboulet R, et al. Mol Cancer Ther. 2024 Dec 3;23(12):1779-1788.

2. Mapperley C, et al. Sci Adv. 2026 Aug 14;12(33):eaec3399.