TRV120027 TFA | AT1R ligand | Probechem Biochemicals

Chemical Structure : TRV120027 TFA

CAS No.:

加入收藏

TRV120027 TFA (TRV027 TFA)

货号: PC-23653Not For Human Use, Lab Use Only.

TRV027 TFA (TRV120027 TFA) is a potent, selective β-arrestin biased ligand of angiotensin II type 1 receptor (AT1R), competitively antagonizes angiotensin II-stimulated G protein signaling.

规格	价格	库存
5 mg	￥1680	In stock
10 mg	￥2580	In stock
25 mg	￥4580	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

TRV027 TFA (TRV120027 TFA) is a potent, selective β-arrestin biased ligand of angiotensin II type 1 receptor (AT1R), competitively antagonizes angiotensin II-stimulated G protein signaling.
TRV027 stimulates β-arrestin recruitment and activates several kinase pathways, including p42/44 mitogen-activated protein kinase, Src, and endothelial nitric-oxide synthase phosphorylation via β-arrestin coupling.
TRV120027 increases cardiomyocyte contractility in vitro.
TRV120027 reduces mean arterial pressure in rats.

物理化学性质&存储条件

分子量	1040.10
分子式	C45H68F3N13O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	D-Alanine, N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl- TFA salt

参考文献

1. Robbins AJ, et al. Br J Clin Pharmacol. 2023 Apr;89(4):1495-1501.

2. Jonathan D Violin, et al. J Pharmacol Exp Ther. 2010 Dec;335(3):572-9.

TRV120027 TFA (TRV027 TFA)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

TRV120027 TFA (TRV027 TFA)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.