TRV055 | AT1R agonist | Probechem Biochemicals

Chemical Structure : TRV055

CAS No.: 25849-90-5

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TRV055 (TRV120055)

货号: PC-27457Not For Human Use, Lab Use Only.

TRV055 (TRV120055) is a selective Gq/11 biased agonist to activate canonical Gq/11 signaling of the angiotensin II type 1 receptor (AT1R).

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
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100 mg		Get quote

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生物&药学活性

TRV055 (TRV120055) is a selective Gq/11 biased agonist to activate canonical Gq/11 signaling of the angiotensin II type 1 receptor (AT1R).
TRV055 (TRV120055) induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts.
TRV055 (TRV120055) activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2.
TRV055 (TRV120055) induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II.

物理化学性质&存储条件

分子量	831.97
分子式	C42H57N9O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-8-Angiotensin II, 2-glycine-5-L-isoleucine-

参考文献

1. Dallagnol JCC, et al. ACS Chem Biol. 2023 Sep 15;18(9):2050-2062.

2. Cui Y, et al. J Am Heart Assoc. 2022 Feb 15;11(4):e022070.

3. Parichatikanond W, et al. Eur J Pharmacol. 2023 Jul 15;951:175780.

TRV055 (TRV120055)

生物&药学活性

物理化学性质&存储条件

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TRV055 (TRV120055)

生物&药学活性

物理化学性质&存储条件

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