TRV023 (TRV120023)

Chemical Structure : TRV023

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货号: PC-27459Not For Human Use, Lab Use Only.

TRV023 (TRV120023) is a selective, β-arrestin-biased agonist of angiotensin II type 1 receptor (AT1R) with pEC50 of 7.66 and 7.62 for β-Arrestin 1 and β-Arrestin 2 respectively.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TRV023 (TRV120023) is a selective, β-arrestin-biased agonist of angiotensin II type 1 receptor (AT1R) with pEC50 of 7.66 and 7.62 for β-Arrestin 1 and β-Arrestin 2 respectively.
TRV023 (TRV120023) promotes cardiac contractility, assessed by pressure-volume loop analyses, while blocking the effects of endogenous ANG II.
TRV023 (TRV120023) has cardioprotective and functional properties in vivo, which are distinct from losartan.
TRV023 (TRV120023) blocks angiotensin-induced hypertrophy, while promoting an increase in sarcomere Ca(2+) response.

物理化学性质&存储条件

分子量	941.11
分子式	C43H68N14O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-Methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-lysyl-L-histidyl-L-prolyl-L-alanine

参考文献

1. Kim KS, et al. Am J Physiol Heart Circ Physiol. 2012 Oct 15;303(8):H1001-10.

2. Pham U, et al. Sci Signal. 2026 Mar 24;19(930):eady4950.

3. Tang W, et al. J Biol Chem. 2014 Oct 10;289(41):28271-83.