TRULI | Lats kinases inhibitor | Probechem Biochemicals

Chemical Structure : TRULI

CAS No.: 2687970-23-4

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TRULI (The Rockefeller University Lats Inhibitor)

货号: PC-49207Not For Human Use, Lab Use Only.

TRULI is a small molecule Yap signaling activator, acts as an ATP-competitive inhibitor of Lats kinases in vitro (Lats1 kinase, IC50=0.2 nM, 10 uM ATP), prevents Yap phosphorylation in the cell-based assays with EC50 of 510 nM.

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生物&药学活性

TRULI is a small molecule Yap signaling activator, acts as an ATP-competitive inhibitor of Lats kinases in vitro (Lats1 kinase, IC50=0.2 nM, 10 uM ATP), prevents Yap phosphorylation in the cell-based assays with EC50 of 510 nM.
TRULI potently inhibits Lats1 kinase activity with IC50 of 4.3nM at 50 uM ATP, and 80 nM at 250 uM ATP.
TRULI inhibits both Lats1 and Lats2 with IC50 of 0.2 nM.
TRULI treatment reduced the proportion of phosphorylated Yap and induced cardiomyocyte proliferation on cardiomyocytes and Müller glia.
TRULI (10 uM, 24 h) reduced Yap phosphorylation on retinal organoids derived from human induced pluripotent stem cells.
TRULI promotes the initial stages of proliferative regeneration of the sensory receptors in the inner ear.

物理化学性质&存储条件

分子量	334.397
分子式	C18H14N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide

参考文献

1. Nathaniel Kastan, et al. Nat Commun. 2021 May 25;12(1):3100.

TRULI (The Rockefeller University Lats Inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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TRULI (The Rockefeller University Lats Inhibitor)

生物&药学活性

物理化学性质&存储条件

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