TRPM5 inhibitor NDNA

Chemical Structure : TRPM5 inhibitor NDNA

CAS No.: 936628-69-2

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货号: PC-20367Not For Human Use, Lab Use Only.

TRPM5 inhibitor NDNA is potent and selecive TRPM5 inhibitor, inhibits Ca2+- induced TRPM5 currents with IC50 of 2.4 nM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TRPM5 inhibitor NDNA is potent and selecive TRPM5 inhibitor, inhibits Ca2+- induced TRPM5 currents with IC50 of 2.4 nM.
NDNA binds to a region critical for channel gating, stabilizes the ion-conducting pore in an apo-like closed conformation.
NDNA inhibits Ca2+-induced TRPM5 activation in a non-competitive manner.
NDNA enhances insulin release, GLP-1 release, and insulin sensitivity.
TPPO dose-dependently inhibited acidic pHe-induced MMP-9 production in B16-BL6 cells (IC50=41 uM), but did not reduce cell viability.
NDNA (10 mg/kg. s.c.) significantly reduced spontaneous lung metastasis, without affecting tumor growth, body weight, or CBG, in tumor bearing mice.

物理化学性质&存储条件

分子量	348.40
分子式	C21H20N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N'-(3,4-dimethoxybenzylidene)-2-(naphthalen-1-yl)acetohydrazide

参考文献

1. Ruan Z, et al. Nat Struct Mol Biol. 2021 Jul;28(7):604-613.

2. Bryant R et al. Patent WO2008097504. Use of a trpm5 inhibitor to regulate insulin and glp-1 release.

3. Toyonobu Maeda, et al. Oncotarget. 2017 Sep 11;8(45):78312-78326.