TRPM5 agonist 64

Chemical Structure : TRPM5 agonist 64

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货号: PC-22256Not For Human Use, Lab Use Only.

TRPM5 agonist 64 is a potent, selective TRPM5 agonist with pEC50 of 7.8 and .1 for mTRPM5 and hTRPM5, respectively.

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生物&药学活性

TRPM5 agonist 64 is a potent, selective TRPM5 agonist with pEC50 of 7.8 and .1 for mTRPM5 and hTRPM5, respectively.
TRPM5 agonist 64 shows high selectivity (>100-fold) over hTRPM8/hTRPV1/hTRPV4/hTRPA1/hTRPM4 (pEC50, <4.8/<4.8/<4.8/5.5/5.5).
TRPM5 agonist 64 shows a statistically significant increase of the fecal parameters after oral administration at 100 mg/kg.

物理化学性质&存储条件

分子量	316.22
分子式	C11H7Cl2N3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Chloro-N-[(5-chloro-2-thiazolyl)methyl]-1,2-benzisothiazol-6-amine

参考文献

1. Alessio Barilli, et al. J Med Chem. 2021 May 13;64(9):5931-5955.

TRPM5 agonist 64

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物理化学性质&存储条件

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TRPM5 agonist 64

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物理化学性质&存储条件

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