TRPM4 inhibitor 5 |CAS: 351424-20-9 Probechem Biochemicals

Chemical Structure : TRPM4 inhibitor 5

CAS No.: 351424-20-9

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TRPM4 inhibitor 5 (TMEM206 inhibitor CBA)

货号: PC-35234Not For Human Use, Lab Use Only.

TRPM4 inhibitor 5 (TMEM206 inhibitor CBA) is a potent and selective inhibitor of TRPM4 with IC50 of 1.5 uM (Na+ influx), also inhibits TMEM206 with IC50 of 9.55 uM.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

TRPM4 inhibitor 5 (TMEM206 inhibitor CBA) is a potent and selective inhibitor of TRPM4 with IC50 of 1.5 uM (Na+ influx), also inhibits TMEM206 with IC50 of 9.55 uM.
TRPM4 inhibitor 5 (TMEM206 inhibitor CBA) selectively inhibits TRPM4 overexpressed in HEK293 cells (IC50=1.8 uM) using classical patch-clamp electrophysiology recordings, shows no significant effect on the TRPM5 current, as well as other TRP family members including TRPM7, TRPM8, TRPV1 and TRPV6.
TRPM4 inhibitor 5 (TMEM206 inhibitor CBA)demonstrates effective and specific inhibition of TMEM206.

物理化学性质&存储条件

分子量	340.156
分子式	C15H11Cl2NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid

参考文献

1. Ozhathil LC, et al. Br J Pharmacol. 2018 Jun;175(12):2504-2519.
2. Sven Kappel, et al. Front Pharmacol. 2024 Mar 7:15:1369513.

TRPM4 inhibitor 5 (TMEM206 inhibitor CBA)

生物&药学活性

物理化学性质&存储条件

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TRPM4 inhibitor 5 (TMEM206 inhibitor CBA)

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物理化学性质&存储条件

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