TRIF agonist AV-C |CAS:620589-62-0 Probechem Biochemicals

Chemical Structure : TRIF agonist AV-C

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TRIF agonist AV-C

货号: PC-63179Not For Human Use, Lab Use Only.

TRIF agonist AV-C is a novel TRIF pathway agonist that activates innate and interferon-associated responses, strongly inhibits replication of ZIKV, CHIKV, and DENV (IC90~5 uM).

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生物&药学活性

TRIF agonist AV-C is a novel TRIF pathway agonist that activates innate and interferon-associated responses, strongly inhibits replication of ZIKV, CHIKV, and DENV (IC90~5 uM).
TRIF agonist AV-C activates IFNAR-mediated transcription and translation of antiviral effector genes, AV-C-mediated, IRF3-dependent innate activation occurs independently of adaptor proteins IPS-1/MAVS and STING but requires TRIF.

物理化学性质&存储条件

分子量	421.446
分子式	C22H16FN3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-fluorophenyl)-2-(5-isopropyl-1,3,4-thiadiazol-2-yl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione

参考文献

1. Pryke KM, et al. MBio. 2017 May 2;8(3). pii: e00452-17.

TRIF agonist AV-C

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物理化学性质&存储条件

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TRIF agonist AV-C

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物理化学性质&存储条件

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