TRIB2 inhibitor 1

Chemical Structure : TRIB2 inhibitor 1

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货号: PC-23446Not For Human Use, Lab Use Only.

TRIB2 inhibitor 1 is a small-molecule binder and inhibitor of Tribbles pseudokinase 2 (TRIB2), downregulates TRIB2 levels at micromolar concentration.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

TRIB2 inhibitor 1 is a small-molecule binder and inhibitor of Tribbles pseudokinase 2 (TRIB2), downregulates TRIB2 levels at micromolar concentration.
Tribbles (TRIBs), first identified in Drosophila as key regulators of the cell cycle, belong to the CAMK subfamily in the human kinome.
The TRIB family includes TRIB1, TRIB2, TRIB3 and STK40.
Pseudokinase TRIB2, a member of the CAMK Ser/Thr protein kinase family, regulates various cellular processes through phosphorylation-independent mechanisms.
TRIB2 acts as a substrate adaptor, facilitating substrate ubiquitination and degradation via its COP1-binding motif.
TRIB2 functions as a switchable scaffold for the assembly and regulation of signaling modules.

物理化学性质&存储条件

分子量	387.42
分子式	C22H18FN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2-fluoropyridin-3-yl)-N-(1,2,3,4-tetrahydroisoquinolin-7-yl)-1H-indazole-3-carboxamide

参考文献

1. Patent WO2021/125802 A1

2. Wen C, et al. Eur J Med Chem. 2024 Nov 1;281:117016.