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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Anaplastic Lymphoma Kinase (ALK)-TRI-611
TRI-611

Chemical Structure : TRI-611

CAS No.: 3117940-39-0

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TRI-611 (TRI 611, TRI611)

货号: PC-28067Not For Human Use, Lab Use Only.

TRI-611 is a potent, selective, CNS-penetrant molecular glue degrader of ALK, promotes the ubiquitination and degradation of ALK fusion alleles with clinically relevant acquired TKI resistance mutations.

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5 mg ￥1780 In stock
10 mg ￥2780 In stock
25 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TRI-611 is a potent, selective, CNS-penetrant molecular glue degrader of ALK, promotes the ubiquitination and degradation of ALK fusion alleles with clinically relevant acquired TKI resistance mutations.
TRI-611 promotes tumor regression with daily oral dosing in both subcutaneous and intracranial models of ALK+ NSCLC.
TRI-611 shows broad selectivity across the global proteome including closely related kinases such as NTRK1, allowing for sustained high target coverage, including in the CNS, without the off-target liabilities that are associated with TKIs.
TRI-611 brings ALK and cereblon together through a unique binding mechanism that works independently of the kinase active site and harnesses the body’s innate protein-degradation machinery to selectively eliminate the ALK fusion protein.

物理化学性质&存储条件

分子量 404.38
分子式 C21H16N4O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(2-oxo-5-((3-phenyl-1,2,4-oxadiazol-5-yl)methyl)benzo[d]oxazol-3(2H)-yl)piperidine-2,6-dione

参考文献

1. Andrew R. Conery, et al. Mol Cancer Ther (2025) 24 (10_Supplement): B064.

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