TREM2 activator 4i | TREM2 agonist | Probechem Biochemicals

Chemical Structure : TREM2 activator 4i

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TREM2 activator 4i (TREM2 agonist)

货号: PC-24790Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TREM2 activator 4i is a specific small molecule activator of triggering receptor expressed on myeloid cells 2 (TREM2) with KD of 19.0 uM in MST assays, 2-fold selectivity over TREM1, induces SYK phosphorylation and significantly enhances microglial phagocytic activity.
TREM2 is a thyroid hormone-regulated gene and its expression in macrophages and microglia is stimulated by thyroid hormone and synthetic thyroid hormone agonists (thyromimetics).

物理化学性质&存储条件

分子量	398.48
分子式	C21H22N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-acetylthiophen-2-yl)-4-methoxy-N-methyl-5-(3-methylenecyclobutane-1-carboxamido)benzamide

参考文献

1. Hossam Nada, et al. bioRxiv [Preprint]. 2025 May 27:2025.05.22.655617.