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首页-小分子抑制剂&激动剂-Others-Other Targets-TREM2 activator 4a
TREM2 activator 4a

Chemical Structure : TREM2 activator 4a

CAS No.:

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TREM2 activator 4a

货号: PC-24791Not For Human Use, Lab Use Only.

TREM2 activator 4a is a specific small molecule activator of triggering receptor expressed on myeloid cells 2 (TREM2) with KD of 12.7 uM, 1.5-fold selectivity over TREM1, induces SYK phosphorylation and significantly enhances microglial phagocytic activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TREM2 activator 4a is a specific small molecule activator of triggering receptor expressed on myeloid cells 2 (TREM2) with KD of 12.7 uM, 1.5-fold selectivity over TREM1, induces SYK phosphorylation and significantly enhances microglial phagocytic activity.

物理化学性质&存储条件

分子量 468.66
分子式 C27H36N2O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-methoxy-N-methyl-3-(3-methylenecyclobutane-1-carboxamido)-5-(3-octylthiophen-2-yl)benzamide

参考文献

1. Hossam Nada, et al. bioRxiv [Preprint]. 2025 May 27:2025.05.22.655617.

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