TRDMT1i (YW1842, YW-1842) | TRDMT1 inhibitor | Probechem Biochemicals

Chemical Structure : TRDMT1i

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TRDMT1i (YW1842, YW-1842, TRDMT1 inhibitor)

货号: PC-28173Not For Human Use, Lab Use Only.

TRDMT1i (YW1842, YW-1842) is a potent small molecule inhibitor of RNA methyltransferase TRDMT1, blocks TRDMT1-mediated m5C formation in DNA-RNA hybrids in vitro and reduces the viability of cancer cell lines.

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100 mg		Get quote

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生物&药学活性

TRDMT1i (YW1842, YW-1842) is a potent small molecule inhibitor of RNA methyltransferase TRDMT1, blocks TRDMT1-mediated m5C formation in DNA-RNA hybrids in vitro and reduces the viability of cancer cell lines.
TRDMT1i (YW1842, YW-1842) exhibits -m5C inhibitory activity almost equivalent to TRDMT1 depletion at the concentration of 2.5 uM.
TRDMT1i (YW1842, YW-1842) specifically sensitizes cells to DNA damage agents in a TRDMT1-dependent manner.
TRDMT1i selectively induces synthetic lethality in MutLα-deficient cells, but not MutLβ and MutS-deficient cells.
TRDMT1i (100 or 200 mg/kg, oral gavage) inhibits growth of MLH1-deficient tumors in BALB/c mice bearing CT26 Mlh1-KO tumors.

物理化学性质&存储条件

分子量	492.57
分子式	C24H20N4O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6,7-dimethoxy-2-(4-(4-(methylsulfonyl)phenyl)-1H-pyrazol-1-yl)-4-(thiophen-3-yl)quinazoline

参考文献

1. Xiaolan Zhu, et al. NAR Cancer. 2021 Mar 22;3(1):zcab010.

2. Ghosh A, et al. Nat Commun. 2026 Aug 10;17(1):9566.