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首页-小分子抑制剂&激动剂-Others-Other Targets-TRAF-STOP 6877002
TRAF-STOP 6877002

Chemical Structure : TRAF-STOP 6877002

CAS No.: 433249-94-6

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TRAF-STOP 6877002 (SMI-6877002, Compound 6877002)

货号: PC-70335Not For Human Use, Lab Use Only.

TRAF-STOP 6877002 (SMI-6877002) is a small molecule inhibitor that blocks the interaction between CD40 and TRAF6 (TRAF-STOP), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity.

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10 mg ￥580 In stock
25 mg ￥980 In stock
50 mg ￥1580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TRAF-STOP 6877002 (SMI-6877002) is a small molecule inhibitor that blocks the interaction between CD40 and TRAF6 (TRAF-STOP), while leaving CD40-TRAF2/3/5 interactions intact, thereby preserving CD40-mediated immunity.
TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation.
TRAF-STOP 6877002 reduces macrophage proliferation in atherosclerotic plaques and reduces the expression of Ki67 in BMDMs.
SMI-6877002 inhibits CD40-TRAF6-dependent inflammation and ameliorates retinal vascular leakage and capillary degeneration in diabetic mice.

物理化学性质&存储条件

分子量 251.32
分子式 C17H17NO
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one

参考文献

1. Chatzigeorgiou A, et al. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2686-91.

2. Seijkens TTP, et al. J Am Coll Cardiol. 2018 Feb 6;71(5):527-542.

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