TR120 | STAT5 inhibitor | Probechem Biochemicals

Chemical Structure : TR120

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TR120 (TR 120, TR-120)

货号: PC-20633Not For Human Use, Lab Use Only.

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1 g		Get quote

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生物&药学活性

TR120 (TR-120) is a potent small molecule STAT5 inhibitor, exhibits antiproliferative in K562 cells with IC50 of 0.12 uM, decreases STAT5 expression in imatinib-sensitive and imatinib-resistant BCR-ABL-expressing leukemia cells.
TR120 is a potent inductor of apoptosis in the BCR-ABL-positive K562 and KCL-22 cell lines and in their imatinib resistant counterpart K562-R and KCL22-R cells in vitro.
TR120 induces a marked decrease in signal transducer and activator of transcription 5 (STAT5) expression in K562 cells.
TR120 exhibits synergistic effects when used in combination with imatinib in both sensitive and resistant cells.

物理化学性质&存储条件

分子量	525.30
分子式	C21H20INO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NC1=C(C(C2=CC(OC)=C(OC)C(OC)=C2)=O)OC3=CC(OC)=CC=C13)CI

参考文献

1. Romagnoli R, et al. Eur J Med Chem. 2016 Jan 27;108:39-52.

2. Grimaudo S, et al. Anticancer Drugs. 2013 Apr;24(4):384-93.

TR120 (TR 120, TR-120)

生物&药学活性

物理化学性质&存储条件

参考文献

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TR120 (TR 120, TR-120)

生物&药学活性

物理化学性质&存储条件

参考文献

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