TR-100 |CAS:1128165-86-5 Probechem Biochemicals

Chemical Structure : TR-100

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TR-100 (TR100;TR 100)

货号: PC-35925Not For Human Use, Lab Use Only.

TR-100 (TR100) is a specific anti-tropomyosin compound that disrupts the actin cytoskeleton via targeting of Tpm3.1-containing actin filaments.

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250 mg		Get quote

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生物&药学活性

TR-100 (TR100) is a specific anti-tropomyosin compound that disrupts the actin cytoskeleton via targeting of Tpm3.1-containing actin filaments.
TR-100 perturbs Tpm3.1-regulated actin filament depolymerisation from the barbed end without affecting the capacity of Tpm3.1 to regulate barbed end actin elongation or bind F-actin.
TR-100 (TR100) is effective in vitro and in vivo in reducing tumor cell growth in neuroblastoma and melanoma models.

物理化学性质&存储条件

分子量	422.617
分子式	C26H38N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Cyano-3-[1-[3-(dimethylamino)propyl]-2-methyl-1H-indol-3-yl]-N-octyl-2-propenamide

参考文献

1. Stehn JR, et al. Cancer Res. 2013 Aug 15;73(16):5169-82.

2. Bonello TT, et al. Sci Rep. 2016 Jan 25;6:19816.

3. Currier MA, et al. Mol Cancer Ther. 2017 Aug;16(8):1555-1565.

4. Kee AJ, et al. Sci Rep. 2018 Mar 15;8(1):4604.

TR-100 (TR100;TR 100)

生物&药学活性

物理化学性质&存储条件

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TR-100 (TR100;TR 100)

生物&药学活性

物理化学性质&存储条件

参考文献

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