TQ416 | PON2 inhibitor | Probechem Biochemicals

Chemical Structure : TQ416

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TQ416 (TQ-416)

货号: PC-26444Not For Human Use, Lab Use Only.

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生物&药学活性

TQ416 is a small molecule paraoxonase 2 (PON2) inhibitor, restores NF-κB transcriptional activity suppressed by N-(3-oxododecanoyl)-L-homoserine lactone (3OC12HSL, C12) with IC50 of 400 nM, rescues 3OC12HSL-induced cell death.
TQ416 inhibits 3OC12HSL hydrolysis and to prevent cytosolic acidification in HEK293T cells.
TQ416 (0.5-5 uM) rescues 3OC12HSL-induced cell death through PON2 inhibition.
Treatment with C12-HSL at 100 μM for 4 h markedly decreased MUC2 production in LS174T cells and TQ416 (1 μM) completely restored this decrease.
TQ416 significantly attenuated the production of IL-8 and IL-1β compared with the C12-HSL alone in LS174T cells.
TQ416 fully restored NF-κB transcriptional responses in LPS-stimulated FRT-NF-κB cells with IC50 of 400 nM.
TQ416 inhibits N-(3-oxo-dodecanoyl) homoserine lactone (C12) action to restore cytokine secretion in LPS-stimulated cells.

物理化学性质&存储条件

分子量	363.48
分子式	C21H21N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,9-dimethyl-1-((2-(p-tolyloxy)ethyl)thio)-[1,2,4]triazolo[4,3-a]quinoline

参考文献

1. Tao S, et al. Sci Rep. 2016 Jul 1;6:28778.

2. Tao S, et al. Life Sci. 2018 May 15;201:81-88.

3. Cathleen D Valentine, et al. Cell Microbiol. 2014 Jan;16(1):1-14.

TQ416 (TQ-416)

生物&药学活性

物理化学性质&存储条件

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TQ416 (TQ-416)

生物&药学活性

物理化学性质&存储条件

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