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首页-小分子抑制剂&激动剂-TGF-beta/Smad-PKC-TPPB
TPPB

Chemical Structure : TPPB

CAS No.: 497259-23-1

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TPPB (PKC activator TPPB)

货号: PC-38022Not For Human Use, Lab Use Only.

TPPB is a highly potent, selectiveand cell permeable protein kinase C (PKC) activator with Ki of 11.9 nM.

规格 价格 库存 数量
2 mg ￥2180 In stock
5 mg ￥3980 In stock
10 mg ￥5880 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TPPB is a highly potent, selectiveand cell permeable protein kinase C (PKC) activator with Ki of 11.9 nM.
TPPB induces differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells.
TPPB also enhances the non-amyloidgenic processing of amyloid precursor protein, increasing secretion of sAPPα.

物理化学性质&存储条件

分子量 501.54
分子式 C27H30F3N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2E,4E)-N-((2S,5S)-5-(hydroxymethyl)-2-isopropyl-1-methyl-3-oxo-1,2,3,4,5,6-hexahydrobenzo[e][1,4]diazocin-8-yl)-5-(4-(trifluoromethyl)phenyl)penta-2,4-dienamide

参考文献

1. Alan P Kozikowski, et al. J Med Chem. 2003 Jan 30;46(3):364-73.

2. Yang HQ, et al. Eur J Neurosci. 2007 Jul;26(2):381-91.

3. Yi P, et al. J Mol Neurosci. 2012 Sep;48(1):234-44.

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