TPP8 | DNA Gyrase inhibitor | Probechem Biochemicals

Chemical Structure : TPP8

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TPP8 (Bacterial DNA Gyrase inhibitor)

货号: PC-49326Not For Human Use, Lab Use Only.

TPP8 is a small molecule antibacterial inhibiting the ATPase of DNA gyrase with IC50 of 0.3 uM, binds and inhibits the ATPase domain of the gyrase B subunit, shows activity against M. abscessus strains with MIC of 0.04-0.2 uM.

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生物&药学活性

TPP8 is a small molecule antibacterial inhibiting the ATPase of DNA gyrase with IC50 of 0.3 uM, binds and inhibits the ATPase domain of the gyrase B subunit, shows activity against M. abscessus strains with MIC of 0.04-0.2 uM.
TPP8 exhibited a markedly higher potency than SPR719 or moxifloxacin.
TPP8 inhibited DNA supercoiling activity of recombinant M. abscessus enzyme.
TPP8 demonstrated proof-of-concept activity against M. abscessus ex vivo and in vivo in macrophage and mouse infection studies.

物理化学性质&存储条件

分子量	482.496
分子式	C23H24F2N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(5-((4-((R)-5-amino-2-azaspiro[3.3]heptan-2-yl)-5,6-difluoro-8-(methylamino)-9H-pyrimido[4,5-b]indol-2-yl)oxy)pyrimidin-2-yl)ethan-1-ol

参考文献

1. Abdeldjalil Madani, et al. Antimicrob Agents Chemother. 2022 Sep 20;66(9):e0066922.

TPP8 (Bacterial DNA Gyrase inhibitor)

生物&药学活性

物理化学性质&存储条件

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TPP8 (Bacterial DNA Gyrase inhibitor)

生物&药学活性

物理化学性质&存储条件

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