欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Cytochrome P450 (CYPs)-TPP-IOA
TPP-IOA

Chemical Structure : TPP-IOA

CAS No.: 1423018-61-4

加入收藏

TPP-IOA

货号: PC-21418Not For Human Use, Lab Use Only.

TPP-IOA is a specific inhibitor of cytochrome c (cyt c) peroxidase activity, inhibits peroxidase activity of cardiolipin-induced cytochrome c peroxidase activity with IC50 of 5 uM.

规格 价格 库存 数量
50 mg Get quote
100 mg Get quote
200 mg Get quote
1 g Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TPP-IOA is a specific inhibitor of cytochrome c (cyt c) peroxidase activity, inhibits peroxidase activity of cardiolipin-induced cytochrome c peroxidase activity with IC50 of 5 uM.
TPP-IOA inhibits apoptosis by preventing cardiolipin oxidation and cytochrome c release to the cytosol.
TPP-IOA dose-dependently inhibits the rate of resorufin formation of the cytochrome c/cardiolipin solution.
TPP-IOA is a specific mitochondria-targeted anti-peroxidase agent inhibiting mono-lyso-CL (MLCL)-cyt c peroxidase activity.
TPP-IOA (5 uM) significantly suppresses resorufin formation in isolated mitochondria.
TPP-IOA prevents phospholipid peroxidation, improves mitochondrial respiration of TAZ-deficient C2C12 myoblasts and restores exercise endurance in a Barth syndrome (BTHS) Drosophila model.

物理化学性质&存储条件

分子量 731.80
分子式 C42H56BrN2O2P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-(3-((12-(1H-imidazol-1-yl)octadec-9-enoyl)oxy)propyl)triphenylphosphonium bromide

参考文献

1. Lucas A Maddalena, et al. Biochim Biophys Acta Bioenerg. 2017 Jan;1858(1):73-85.

2. Kagan VE, et al. Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome. Nat Metab. 2023 Nov 23. doi: 10.1038/s42255-023-00926-4.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: