TPN729 | PDE5 inhibitor | Probechem Biochemicals

Chemical Structure : TPN729

CAS No.: 936951-20-1

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TPN729 (TPN 729)

货号: PC-63028Not For Human Use, Lab Use Only.

TPN729 is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM, shows better selectivity profile 2.5 times higher than sildenafil against PDE6 and 500 times higher than tadalafil against PDE11.

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10 mg	￥3980	In stock
25 mg	￥5980	In stock
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生物&药学活性

TPN729 (TPN-729) is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM, shows better selectivity profile 2.5 times higher than sildenafil against PDE6 and 500 times higher than tadalafil against PDE11.
TPN729 selectively inhibits PDE5 and blocks the degradation of cyclic guanosine monophosphate, and is a promising PDE5 inhibitor providing fewer side effects and better compliance.

物理化学性质&存储条件

分子量	516.661
分子式	C25H36N6O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-methyl-4-propoxy-N-[2-(1-pyrrolidinyl)ethyl]benzenesulfonamide

参考文献

1. Wang Z, et al. J Sex Med. 2013 Nov;10(11):2790-7.

2. Zhu Y, et al. J Pharm Biomed Anal. 2016 Jan 5;117:217-26.

TPN729 (TPN 729)

生物&药学活性

物理化学性质&存储条件

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TPN729 (TPN 729)

生物&药学活性

物理化学性质&存储条件

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