TPN672 | 5-HT agonist | Probechem Biochemicals

Chemical Structure : TPN672

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TPN672 (TPN 672)

货号: PC-72159Not For Human Use, Lab Use Only.

TPN672 (TPN 672) is a novel antipsychotic compound with high affinity for serotonin and dopamine receptors 5-HT1AR, (Ki=0.23 nM), 5-HT2AR (Ki=2.58 nM) as well as moderate affinity for D3R (Ki=11.55 nM) and D2R (Ki=17.91 nM).

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生物&药学活性

TPN672 (TPN 672) is a novel antipsychotic compound with high affinity for serotonin and dopamine receptors 5-HT1AR, (Ki=0.23 nM), 5-HT2AR (Ki=2.58 nM) as well as moderate affinity for D3R (Ki=11.55 nM) and D2R (Ki=17.91 nM).
TPN672 acted as a potent 5-HT1AR agonist, D2R/D3R partial agonist, and 5-HT2AR antagonist in vitro functional assays.
TPN672 displayed robust antipsychotic efficacy in rodent models (e.g., blocking phencyclidine-induced hyperactivity), significantly better than aripiprazole, and ameliorated negative symptoms and cognitive deficits in the sociability test, dark avoidance response, Morris water maze test, and novel object recognition test.

物理化学性质&存储条件

分子量	505.589
分子式	C27H27N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM i nDMSO
Chemical Name/SMILES	7-(2-(4-(benzothiophen-4-yl) piperazin-1-yl)ethyl)quinolin-2(1H)-one maleate

参考文献

1. Wang Y, et al. J Pharmacol Exp Ther. 2021 Jul;378(1):20-30.

TPN672 (TPN 672)

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物理化学性质&存储条件

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TPN672 (TPN 672)

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