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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-TPN-0157345
TPN-0157345

Chemical Structure : TPN-0157345

CAS No.: 1620589-95-8

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TPN-0157345 (TPN0157345)

货号: PC-24832Not For Human Use, Lab Use Only.

TPN-0157345 is a small molecule inhibitor of Mycobacterium tuberculosis (M.tb) mycolic acid exporter MmpL3, targets cell wall biosynthesis, inhibits aerobically cultured M. tuberculosis H37Rv with IC90 of 3.3 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TPN-0157345 is a small molecule inhibitor of Mycobacterium tuberculosis (M.tb) mycolic acid exporter MmpL3, targets cell wall biosynthesis, inhibits aerobically cultured M. tuberculosis H37Rv with IC90 of 3.3 uM.
TPN-0157345 has IC90 of 1.4 uM against intracellular M. tuberculosis H37Rv in THP-1 macrophages.

物理化学性质&存储条件

分子量 411.52
分子式 C21H25N5O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-methyl-4-(1H-pyrazol-1-yl)-N-(1-(pyridin-4-ylmethyl)piperidin-4-yl)benzenesulfonamide

参考文献

1. Allen R, et al. Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0103724.

2. Maruti Naik, et al. ACS Med Chem Lett. 2014 Jul 11;5(9):1005-9.

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