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首页-小分子抑制剂&激动剂-NF-κB Pathway-IκB kinase (IKK)-TPCA-1
TPCA-1

Chemical Structure : TPCA-1

CAS No.: 507475-17-4

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TPCA-1 (IKK-2 Inhibitor IV)

货号: PC-42243Not For Human Use, Lab Use Only.

TPCA-1 (IKK-2 Inhibitor IV) is a potent, selective and orally bioavailable IKK-2 inhibitor with IC50 of 63 nM, TNF cell IC50 of 0.4 uM.

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5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TPCA-1 (IKK-2 Inhibitor IV) is a potent, selective and orally bioavailable IKK-2 inhibitor with IC50 of 63 nM, TNF cell IC50 of 0.4 uM.
TPCA-1 displays >100-fold selectivity over IKK-1.

物理化学性质&存储条件

分子量 279.2901
分子式 C12H10FN3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-

参考文献

1. Baxter A, et al. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2817-22.

2. Park BK, et al. Nat Med. 2007 Jan;13(1):62-9.

3. Amaya M, et al. PLoS One. 2014 Feb 19;9(2):e86745.

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