TPC2-A1-N

Chemical Structure : TPC2-A1-N

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货号: PC-49241Not For Human Use, Lab Use Only.

TPC2-A1-N is a membrane permeable isoform-selective small molecule agonist agonist of two-pore channel 2 (TPC2) with EC50 of 7.8 uM in cell-based Ca2+ signals assays, mediates changes in intracellular calcium in the absence of extracellular calcium.

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生物&药学活性

TPC2-A1-N is a membrane permeable isoform-selective small molecule agonist agonist of two-pore channel 2 (TPC2) with EC50 of 7.8 uM in cell-based Ca2+ signals assays, mediates changes in intracellular calcium in the absence of extracellular calcium.
TPC2-A1-N evokes Na+ currents in isolated endo-lysosomes with EC50 of 0.6 uM in endo-lysosomal patch-clamp experiments.
TPC2-A1-P but not TPC2-A1-N promoted lysosomal exocytosis.
TPC2-A1-N increases the pH in the lysosomal lumen in a TPC2-dependent manner, TPC2-A1-P has no significant effect on lysosomal pH.

物理化学性质&存储条件

分子量	401.166
分子式	C17H9Cl2F3N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-cyano-3-(3,5-dichlorophenyl)-3-hydroxy-N-(4-(trifluoromethyl)phenyl)acrylamide

参考文献

1. Susanne Gerndt, et al. Elife. 2020 Mar 16;9:e54712.

TPC2-A1-N

生物&药学活性

物理化学性质&存储条件

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TPC2-A1-N

生物&药学活性

物理化学性质&存储条件

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