TPA023B |CAS:425377-76-0 Probechem Biochemicals

Chemical Structure : TPA023B

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TPA023B (TPA 023B)

货号: PC-62768Not For Human Use, Lab Use Only.

TPA023B is a potent, α2/α3 subtype-selective GABAA receptor partial agonist with Ki of 2.0 and 1.8 nM, does not affect the functioning of the α1 subtype.

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生物&药学活性

TPA023B is a potent, α2/α3 subtype-selective GABAA receptor partial agonist with Ki of 2.0 and 1.8 nM, does not affect the functioning of the α1 subtype.
TPA023B demonstrates anxiolytic effects in rodent and primate models of anxiety, with no significant effects in ataxia and/or myorelaxation.

物理化学性质&存储条件

分子量	391.382
分子式	C21H15F2N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2',6-difluoro-5'-[3-(1-hydroxy-1-methylethyl) imidazo[1,2-b][1,2,4]triazin-7-yl][1,1'-biphenyl]-2-carbonitrile

参考文献

1. Van Laere K, et al. Biol Psychiatry. 2008 Jul 15;64(2):153-61.

2. Russell MG, et al. J Med Chem. 2006 Feb 23;49(4):1235-8.

3. Atack JR, et al. J Psychopharmacol. 2011 Mar;25(3):329-44.

TPA023B (TPA 023B)

生物&药学活性

物理化学性质&存储条件

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TPA023B (TPA 023B)

生物&药学活性

物理化学性质&存储条件

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