TP455 |CAS:2042563-95-9 Probechem Biochemicals

Chemical Structure : TP455

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TP455 (TP-455;TP 455)

货号: PC-35297Not For Human Use, Lab Use Only.

TP455 (TP-455) is a highly potent, selective A2A adenosine receptor inverse agonist with IC50 of 1.9 nM in cyclic AMP assays in hA2A CHO cells.

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生物&药学活性

TP455 (TP-455) is a highly potent, selective A2A adenosine receptor inverse agonist with IC50 of 1.9 nM in cyclic AMP assays in hA2A CHO cells.
TP455 proved to be more potent than morphine in writhing and tail immersion tests in mice with ED50 of 0.0328 mg/kg, exhibits great analgesic activity with an ED50 of 0.134 ± 0.011 mg/kg and minimum effective dose of 0.01 mg/kg.
TP455 antagonizes CGS 21680-induced cell proliferation in cancer cell lines, inhibits GS 21680-dependent pERK1/2, pJNK MAPK kinase, and pAKT activation.

物理化学性质&存储条件

分子量	353.4
分子式	C17H15N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-furanyl)-N5-(2-methoxybenzyl)[1,3]thiazolo[5,4-d]pyrimidine-5,7-diammine

参考文献

1. Gessi S, et al. Front Pharmacol. 2017 Dec 1;8:888. doi: 10.3389/fphar.2017.00888.

2. Varano F, et al. J Med Chem. 2016 Dec 8;59(23):10564-10576.

TP455 (TP-455;TP 455)

生物&药学活性

物理化学性质&存储条件

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TP455 (TP-455;TP 455)

生物&药学活性

物理化学性质&存储条件

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