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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-TP0463518
TP0463518

Chemical Structure : TP0463518

CAS No.: 1558021-37-6

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TP0463518 (TP-0463518, TP 0463518)

货号: PC-63449Not For Human Use, Lab Use Only.

TP0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 13 nM and 18 nM for human and rat PHD2, respectively.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
50 mg ￥5580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TP0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 13 nM and 18 nM for human and rat PHD2, respectively.
TP0463518 demonstrates to promote the production of erythropoietin (EPO) following oral administration in mice and rats.
TP0463518 shows potential for treatment of renal anemia.

物理化学性质&存储条件

分子量 431.829
分子式 C20H18ClN3O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1-((6-(4-chlorophenoxy)pyridin-3-yl)methyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carbonyl)glycine

参考文献

1. Hamada M, et al. Bioorg Med Chem Lett. 2018 Apr 16. pii: S0960-894X(18)30351-2.

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