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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-SGLT-TP0438836
TP0438836

Chemical Structure : TP0438836

CAS No.: 957772-01-9

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TP0438836 (TP-0438836, TP 0438836)

货号: PC-35748Not For Human Use, Lab Use Only.

TP0438836 is a potent, low-absorbable sodium-dependent glucose cotransporter (SGLT) inhibitor with IC50 of 28 nM/7 nM for hSGLT1 and hSGLT2, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TP0438836 is a potent, low-absorbable sodium-dependent glucose cotransporter (SGLT) inhibitor with IC50 of 28 nM/7 nM for hSGLT1 and hSGLT2, respectively.
    TP0438836 shows a desirable PK profile in Sprague-Dawley (SD) rats and a favorable glucose-lowering effect in diabetic rats.

    物理化学性质&存储条件

    分子量 550.605
    分子式 C27H38N2O10
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-3-(4-(4-hydroxy-2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenethyl)urea

    参考文献

    1. Kuroda S, et al. Bioorg Med Chem Lett. 2018 Dec 1;28(22):3534-3539.

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