TP-472 | BRD9/BRD7 inhibitor | Probechem Biochemicals

Chemical Structure : TP-472

CAS No.: 2079895-62-6

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TP-472 (TP472, TP 472)

货号: PC-62273Not For Human Use, Lab Use Only.

TP-472 is a novel BRD9/7 chemical probe that has excellent potency (BRD9 KD=33nM, BRD7 KD=340 nM by ITC), >30 fold selectivity over all other bromodomain family members except BRD7 and is cell active (EC50 320 nM in a BRD9 NanoBRET assay).

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10 mg	￥1880	In stock
25 mg	￥2980	In stock
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生物&药学活性

TP-472 is a novel BRD9/7 chemical probe that has excellent potency (BRD9 KD=33nM, BRD7 KD=340 nM by ITC), >30 fold selectivity over all other bromodomain family members except BRD7 and is cell active (EC50 320 nM in a BRD9 NanoBRET assay).
TP-472 has a good PK profile and is suitable for in vivo applications.

物理化学性质&存储条件

分子量	333.391
分子式	C20H19N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(6-acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide

参考文献

1. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.

TP-472 (TP472, TP 472)

生物&药学活性

物理化学性质&存储条件

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TP-472 (TP472, TP 472)

生物&药学活性

物理化学性质&存储条件

参考文献

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