TP-3654 |CAS:1361951-15-6 Probechem Biochemicals

Chemical Structure : TP-3654

CAS No.: 1361951-15-6

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TP-3654 (TP3654;TP 3654)

货号: PC-42322Not For Human Use, Lab Use Only.

TP-3654 is a potent, selective, orally active second-generation PIM inhibitor with Ki of 5, 42 and 239 nM for Pim1, 2 and 3, respectively.

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25 mg	￥1880	In stock
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生物&药学活性

TP-3654 is a potent, selective, orally active second-generation PIM inhibitor with Ki of 5, 42 and 239 nM for Pim1, 2 and 3, respectively.
TP-3654 exhibits submicromolar activity in UM-UC-3 bladder cancer cell line.
TP-3654 displays favorabl hERG and CYP450 inhibition profiles compared with SGI-1776, reduces tumor growth in vivo xenografts.

物理化学性质&存储条件

分子量	418.4553096
分子式	C22H25F3N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 10 mM
Chemical Name/SMILES	Cyclohexanemethanol, α,α-dimethyl-4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]-, trans-

参考文献

1. Foulks JM, et al. Neoplasia. 2014 May;16(5):403-12.

TP-3654 (TP3654;TP 3654)

生物&药学活性

物理化学性质&存储条件

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TP-3654 (TP3654;TP 3654)

生物&药学活性

物理化学性质&存储条件

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