TP-18 | EP2/EP4 antagonist | Probechem Biochemicals

Chemical Structure : TP-18

加入收藏

TP-18 (TP18, EP2/EP4 antagonist)

货号: PC-27006Not For Human Use, Lab Use Only.

TP-18 is a potent, selective, orally available dual PGE2 receptor EP2/EP4 antagonist with IC50 of 9.5/3.3 nM respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

TP-18 is a potent, selective, orally available dual PGE2 receptor EP2/EP4 antagonist with IC50 of 9.5/3.3 nM respectively.
TP-18 potently suppressed PGE2-induced β-arrestin recruitment in CHO-EP2 cells and CHO-EP4 cells with IC50 values of 11.1 and 10.5 nM, respectively.
TP-18 displays robust antagonism against EP2 and EP4 in GPCR assay based on Gα16-mediated calcium flux, with high selectivity of >1,000-fold against the EP1 and EP3 receptors.
TP-18 physically occupies the PGE2-binding pockets of EP2 and EP4 structures.
TP-18 triggers CD8+ T cell-mediated anti-tumor immune response to promote tumor regression, demonstrates superior anti-tumor efficacy compared to EP2i, EP4i, and celecoxib.
TP-18 boosts CD8+ T cell response via depleting immunosuppressive VSIG4high tumor-associated macrophages (TAMs).
TP-18 impairs expression of immune checkpoint molecule VSIG4 in TAMs through inactivating Gαs-PKA-CREB signaling.
TP-18 overcomes primary and acquired resistance to anti-PD-1 therapy in colorectal cancer models, improves the efficacy of anti-PD-1 therapy in patient-derived tumor immune organoids.

物理化学性质&存储条件

分子量	448.50
分子式	C25H25FN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-ethoxy-4-(6-((2-(7-fluoro-2,4-dimethyl-1H-indol-3-yl)ethyl)amino)pyrimidin-4-yl)benzoic acid

参考文献

1. Zhang Y, et al. Cell Rep. 2026 May 28;45(6):117450.

TP-18 (TP18, EP2/EP4 antagonist)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

TP-18 (TP18, EP2/EP4 antagonist)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.