TP-10

Chemical Structure : TP-10

CAS No.: 898563-00-3

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货号: PC-24217Not For Human Use, Lab Use Only.

TP-10 is a potent, selective inhibitor of cyclic nucleotide phosphodiesterase PDE10A with IC50 of 0.8 nM.

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10 mg	￥2180	In stock
25 mg	￥3780	In stock
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TP-10 is a potent, selective inhibitor of cyclic nucleotide phosphodiesterase PDE10A with IC50 of 0.8 nM.
increases the responsiveness of striatal neurons to electrical stimulation of the ipsilateral frontal cortex.
TP-10 also increases cortically evoked spike activity in a stimulus intensity- and dose-dependent manner.
TP-10 administration increased the incidence of antidromically activated (i.e., SNr+) MSNs.

物理化学性质&存储条件

分子量	460.46
分子式	C26H19F3N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((4-(4-(pyridin-4-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl)phenoxy)methyl)quinoline

参考文献

1. Schmidt CJ, et al. J Pharmacol Exp Ther. 2008 May;325(2):681-90.

2. Threlfell S, et al. J Pharmacol Exp Ther. 2009 Mar;328(3):785-95.

3. Hamaguchi W, et al. 2014;62(12):1200-1213.

TP-10

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TP-10

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