Itacnosertib (TP-0184) | ALK2 inhibitor | Probechem Biochemicals

Chemical Structure : TP-0184

CAS No.: 1628870-27-8

加入收藏

TP-0184 (Itacnosertib, TP0184)

货号: PC-21414Not For Human Use, Lab Use Only.

Itacnosertib (TP-0184) is a novel potent, selective inhibitor of type I bone morphogenetic protein (BMP) receptor ACVR1 (activin A receptor-type 1, ALK2) and FLT3 with IC50 of 8.0 nM (ALK2).

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2880	In stock
25 mg	￥4580	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Itacnosertib (TP-0184) is a novel potent, selective inhibitor of type I bone morphogenetic protein (BMP) receptor ACVR1 (activin A receptor-type 1, ALK2) and FLT3 with IC50 of 8.0 nM (ALK2).
TP-0184 binds to both ACVR1 and FLT3 with high affinity and inhibits FLT3/ACVR1 downstream signaling.
TP-0184 selectively caused growth arrest in FLT3-mutated AML cell lines.
Treatment with TP-0184 or in combination with BCL2 inhibitor, venetoclax dramatically inhibited leukemia growth in FLT3-mutated AML cell lines and patient-derived xenograft models in a dose-dependent manner.

物理化学性质&存储条件

分子量	468.57
分子式	C26H28N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N4-([2,2'-bipyridin]-3-yl)-N2-(3-methoxy-4-(4-methylpiperazin-1-yl)phenyl)pyrimidine-2,4-diamine

参考文献

1. Anudishi Tyagi, et al. Leukemia. 2023 Nov 25. doi: 10.1038/s41375-023-02086-6.

TP-0184 (Itacnosertib, TP0184)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

TP-0184 (Itacnosertib, TP0184)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.