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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Acetyl-CoA Carboxylase (ACC)-TOFA
TOFA

Chemical Structure : TOFA

CAS No.: 54857-86-2

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TOFA (RMI14514;MDL14514)

货号: PC-42306Not For Human Use, Lab Use Only.

TOFA (RMI14514, MDL14514) is an indirect, allosteric inhibitor of Acetyl-CoA carboxylase-α (ACCA) and fatty acid synthesis.

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25 mg ￥880 In stock
50 mg ￥1280 In stock
100 mg ￥1880 In stock
200 mg Get quote
1 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TOFA (RMI14514, MDL14514) is an indirect, allosteric inhibitor of Acetyl-CoA carboxylase-α (ACCA) and fatty acid synthesis.
TOFA (RMI14514, MDL14514) is converted to TOFyl-CoA, exerts an allosteric inhibition on ACCA.
TOFA (RMI14514, MDL14514) lowers blood lipids and inhibits fatty acid synthesis with minimal effects on liver weight and liver fat content.
TOFA (RMI14514, MDL14514) also induces human cancer cell apoptosis through disturbing their fatty acid synthesis.

物理化学性质&存储条件

分子量 324.45498
分子式 C19H32O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 34 mg/mL
Chemical Name/SMILES

2-Furancarboxylic acid, 5-(tetradecyloxy)-

参考文献

1. Parker RA, et al. J Med Chem. 1977 Jun;20(6):781-91.

2. McCune SA, et al. J Biol Chem. 1979 Oct 25;254(20):10095-101.

3. Wang C, et al. Biochem Biophys Res Commun. 2009 Jul 31;385(3):302-6.

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