TNP-470 | MetAP2 inhibitor | Probechem Biochemicals

Chemical Structure : TNP-470

CAS No.: 129298-91-5

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TNP-470 (TNP470, AGM-1470, AGM1470)

货号: PC-63314Not For Human Use, Lab Use Only.

TNP-470 (AGM-1470) is a specific, rreversible MetAP-2 inhibitor and and annti-angiogenic compound, inhibits endothelial cell proliferation and angiogenesis.

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5 mg	￥1580	In stock
10 mg	￥2580	In stock
25 mg	￥4280	In stock
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100 mg		Get quote

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生物&药学活性

TNP-470 (AGM-1470) is a specific, rreversible MetAP-2 inhibitor and and annti-angiogenic compound, inhibits endothelial cell proliferation and angiogenesis.
TNP-470 has anti-growth factor properties and inhibits the activation of Cdk 2 and phosphorylation of RB protein, inhibits potently PDGF- and bFGF-stimulated proliferation of rat mesangial cells in vitro (IC50 = 50 pg/ml).
TNP-470 inhibits tumor growth and metastasis of rodent tumors.
TNP-470 does not bind to or inhibit MetAP-1.

物理化学性质&存储条件

分子量	401.884
分子式	C19H28ClNO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4S,5S,6R)-5-Methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl (2-chloroacetyl)carbamate

参考文献

1. Yamaoka M, et al. Cancer Res. 1993 Sep 15;53(18):4262-7.

2. Haraguchi M, et al. Kidney Int. 1997 Jun;51(6):1838-46.

3. Garrabrant T, et al. Angiogenesis. 2004;7(2):91-6.

4. Ingber D, et al. Nature. 1990 Dec 6;348(6301):555-7.

TNP-470 (TNP470, AGM-1470, AGM1470)

生物&药学活性

物理化学性质&存储条件

参考文献

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TNP-470 (TNP470, AGM-1470, AGM1470)

生物&药学活性

物理化学性质&存储条件

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