Batoprotafib (TNO155) | SHP2 inhibitor | Probechem Biochemicals

Chemical Structure : TNO155

CAS No.: 1801765-04-7

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TNO155 (Batoprotafib, TNO-155)

货号: PC-38180Not For Human Use, Lab Use Only.

Batoprotafib (TNO155) is a highly potent, selective, orally active, and allosteric SHP2 (PTPN11) inhibitor with IC50 of 11 nM.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
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生物&药学活性

Batoprotafib (TNO155) is a highly potent, selective, orally active, and allosteric SHP2 (PTPN11) inhibitor with IC50 of 11 nM.
TNO155 is efficacious in acquired resistance models of EGFRi and demonstrates combination benefits with EGFR inhibitors, inhibits EGFR-mutant NSCLC cell lines NCI-H3255, HCC827, and PC9 with IC50 of <1.5 uM.
TNO155 also sensitizes BRAF-mutant colorectal cancer to inhibitors of BRAF and MEK, and enhances the efficacy of KRASG12C inhibitors against KRASG12C lung and colorectal cancers.
Ribociclib enhances the efficacy of TNO155 in both RTK-activated and KRAS-mutant cancers.
NO155 inhibits immune-suppressive macrophages and synergizes with PD1 blockade.

物理化学性质&存储条件

分子量	421.948
分子式	C18H24ClN7OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-amine

参考文献

1. LaMarche MJ, et al. J Med Chem. 2020 Nov 25;63(22):13578-13594.

2. Liu C, et al. Clin Cancer Res. 2021 Jan 1;27(1):342-354.

TNO155 (Batoprotafib, TNO-155)

生物&药学活性

物理化学性质&存储条件

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TNO155 (Batoprotafib, TNO-155)

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物理化学性质&存储条件

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