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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-TNG260
TNG260

Chemical Structure : TNG260

CAS No.: 2935964-98-8

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TNG260 (TNG-260, TNG 260)

货号: PC-20671Not For Human Use, Lab Use Only.

TNG260 (TNG-260) is a potent, CoREST-selective deacetylase (CoreDAC) inhibitor, inhibits HDAC1 with 10-fold selectivity over HDAC3 in cells.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TNG260 (TNG-260) is a potent, CoREST-selective deacetylase (CoreDAC) inhibitor, inhibits HDAC1 with 10-fold selectivity over HDAC3 in cells.
TNG260 displays 500-fold selectivity for the CoREST complex over the other HDAC1-containing complexes, NuRD and Sin3.
TNG260 re-sensitizes α-PD1 resistant STK11-mutant MC38 syngeneic tumor model with α-PD1.
The combination of TNG260 and α-PD1 led to durable complete tumor regressions in α-PD1 resistant STK11-mutant MC38 syngeneic tumor models.
TNG260 has no anti-tumor efficacy in immunocompromised mice, indicating the tumor cell killing with TNG260 is immune-mediated and not due to direct cell killing.
TNG260 also decreased intratumoral infiltration of neutrophils, an immune suppressive cell type associated with STK11-mutant NSCLC.
TNG260 reverses the immune evasion phenotype caused by loss of STK11 and induces tumor regressions in an STK11-mutant model in combination with α-PD1.

物理化学性质&存储条件

分子量 383.44
分子式 C20H18FN3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-N-(4-Amino-4'-fluoro-[1,1'-biphenyl]-3-yl)-4-(S-methylsulfonimidoyl)benzamide

参考文献

1. Ahronian LG, et al. Cancer Res. 2025 Aug 29. doi: 10.1158/0008-5472.CAN-25-0998.

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