TNFR1 inhibitor FKC | TNFR1 inhibitor | Probechem Biochemicals

Chemical Structure : TNFR1 inhibitor FKC

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TNFR1 inhibitor FKC (Peptide FKCRRWQWRMKK)

货号: PC-22074Not For Human Use, Lab Use Only.

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生物&药学活性

TNFR1 inhibitor FKC is an allosteric inhibitor targets TNFR1 (Tumor necrosis factor receptor 1), inhibits TNFR1 activation by altering the conformational states of the receptor dimer without blocking receptor-ligand interaction or disrupting receptor dimerization.
FKC binds to TNFR1 cysteine-rich domains (CRD2/3) and perturbs the conformational dynamics required for receptor activation.
FKC increases the frequency in the opening of both CRD2/3 and CRD4 in the receptor dimer, as well as induces a conformational opening in the cytosolic regions of the receptor.
FKC impedes the recruitment of downstream signaling molecules of TNFR1.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Jialiu Zeng, et al. Proc Natl Acad Sci U S A. 2024 Apr 2;121(14):e2308132121.

TNFR1 inhibitor FKC (Peptide FKCRRWQWRMKK)

生物&药学活性

物理化学性质&存储条件

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TNFR1 inhibitor FKC (Peptide FKCRRWQWRMKK)

生物&药学活性

物理化学性质&存储条件

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