TN2008 | SRSF1 inhibitor | Probechem Biochemicals

Chemical Structure : TN2008

CAS No.: 484-76-4

加入收藏

TN2008 (Okanin)

货号: PC-23912Not For Human Use, Lab Use Only.

TN2008 is an effective serine arginine-rich splicing factor 1 (SRSF1) inhibitor with IC50 of 144 uM, exhibits high affinity for recombinant SRSF1 with Kd of 5.13 uM in SPR assays.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg	￥5580	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

TN2008 is an effective serine arginine-rich splicing factor 1 (SRSF1) inhibitor with IC50 of 144 uM, exhibits high affinity for recombinant SRSF1 with Kd of 5.13 uM in SPR assays.
TN2008 effectively inhibits SRSF1 protein function, exhibiting a binding energy of –5.1 kcal/mol.
TN2008 has the potential to enhance Foxo1 expression in Cd8+T cells, exhibits significant inhibition in cell growth in Hep1-6-OVA cells.
TN2008 treatment (15 mg/kg) effectively inhibits tumor growth in Hep1-6-OVA cancer model, boosts T cell functionality and synergizes with anti-PD-1 therapy.

物理化学性质&存储条件

分子量	288.26
分子式	C15H12O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(3,4-Dihydroxyphenyl)-1-(2,3,4-trihydroxyphenyl)prop-2-en-1-one

参考文献

1. Zhu GQ, et al. Signal Transduct Target Ther. 2025 Jan 22;10(1):25.

TN2008 (Okanin)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

TN2008 (Okanin)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.