TN-2 | Tubulin/NRP1 inhibitor | Probechem Biochemicals

Chemical Structure : TN-2

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TN-2 (Tubulin/NRP1 inhibitor TN-2)

货号: PC-21448Not For Human Use, Lab Use Only.

TN-2 is a potent, dual tubulin/NRP1-targeting inhibitor with IC50 of 0.71 uM (tubulin polymerization) and 0.85 uM (NRP-1), inhibits proliferation and angiogenesis of tumor cells.

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生物&药学活性

TN-2 is a potent, dual tubulin/NRP1-targeting inhibitor with IC50 of 0.71 uM (tubulin polymerization) and 0.85 uM (NRP-1), inhibits proliferation and angiogenesis of tumor cells.
TN-2 significantly inhibits the viability of several human prostate tumor cell lines.
TN-2 inhibits tubulin polymerization and cause G2/M arrest, thereby inducing cell apoptosis.
TN-2 also suppress cell tube formation, migration, and invasion.
TN-2 shows obvious antitumor effects on the PC-3 cell-derived xenograft model with negligible side effects and good pharmacokinetic profiles.

物理化学性质&存储条件

分子量	571.63
分子式	C28H37N5O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-(4-((2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)amino)-4-oxobutanoyl)-L-arginine

参考文献

1. Lufeng Zheng, et al. Journal of Medicinal Chemistry. 2023.

TN-2 (Tubulin/NRP1 inhibitor TN-2)

生物&药学活性

物理化学性质&存储条件

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TN-2 (Tubulin/NRP1 inhibitor TN-2)

生物&药学活性

物理化学性质&存储条件

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