TMinh-23 | TMEM16A inhibitor | Probechem Biochemicals

Chemical Structure : TMinh-23

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TMinh-23 (TMEM16A inhibitor)

货号: PC-47048Not For Human Use, Lab Use Only.

TMinh-23 is (Compound 10bm) is a potent, selective inhibitor of transmembrane protein 16A (TMEM16A or ANO1, DOG1, ORAOV2, TAOS-2) with IC50 of 30 nM in short-circuit current assays, weakly inhibits TMEM16B (IC50=400 nM, 13 -fold selectivity).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TMinh-23 is (Compound 10bm) is a potent, selective inhibitor of transmembrane protein 16A (TMEM16A or ANO1, DOG1, ORAOV2, TAOS-2) with IC50 of 30 nM in short-circuit current assays, weakly inhibits TMEM16B (IC50=400 nM, 13 -fold selectivity).
TMinh-23 fully inhibited calcium-activated TMEM16A chloride current with nanomolar potency in Fischer rat thyroid cells expressing TMEM16A, and in primary cultures of rat vascular smooth muscle cells.
TMinh-23 reduced vasoconstriction caused by the thromboxane mimetic U46619 in mesenteric resistance arteries of wild-type and spontaneously hypertensive rats, with a greater inhibition in spontaneously hypertensive rats.
TMinh-23 blocked vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats.

物理化学性质&存储条件

分子量	457.334
分子式	C19H19BrF2N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-bromodifluoroacetylamino-5,6,7,8-tetrahydro-4Hcyclohepta[b]thiophene-3-carboxylic acid o-tolylamide

参考文献

1. Onur Cil, et al. Kidney Int. 2021 Aug;100(2):311-320.

2. Eric C Truong, et al. J Med Chem. 2017 Jun 8;60(11):4626-4635.