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首页-小分子抑制剂&激动剂-Others-Other Targets-TMX-4102
TMX-4102

Chemical Structure : TMX-4102

CAS No.:

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TMX-4102 (TMX4102)

货号: PC-20165Not For Human Use, Lab Use Only.

TMX-4102 (TMX4102) is a highly potent, selective PIP4K2C binder with KD of 0.45 nM, shows no affinity for PIP4K2B and PIP4K2A (KD>10 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TMX-4102 (TMX4102) is a highly potent, selective PIP4K2C binder with KD of 0.45 nM, shows no affinity for PIP4K2B and PIP4K2A (KD>10 uM).
    TMX-4102 exhibited selectivity for PIP4K2C over other lipid kinase isoforms and the non-lipid kinases in the KINOMEscan.

    物理化学性质&存储条件

    分子量 469.93
    分子式 C26H20ClN5O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-((4-([1,1'-biphenyl]-3-yl)-5-chloropyrimidin-2-yl)amino)-6,6a,7,8-tetrahydro-9H-pyrido[2,3-b]pyrrolo[1,2-d][1,4]oxazin-9-one

    参考文献

    1. Teng M, et al. Angew Chem Int Ed Engl. 2023 Mar 10:e202302364.

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