TMPRSS2 inhibitor BC-11

Chemical Structure : TMPRSS2 inhibitor BC-11

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货号: PC-49423Not For Human Use, Lab Use Only.

TMPRSS2 inhibitor BC-11 is a specific, covalent transmembrane protease serine 2 (TMPRSS2) inhibitor with IC50 of 1.44 uM in vitro TMPRSS2 enzymatic assay.

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生物&药学活性

TMPRSS2 inhibitor BC-11 is a specific, covalent transmembrane protease serine 2 (TMPRSS2) inhibitor with IC50 of 1.44 uM in vitro TMPRSS2 enzymatic assay.
BC-11 is inactive against three proteases (furin, CATSB, and CATSL).
BC-11 showed modest inhibition of SARS-CoV-2 entry with EC50 of 66 uM.
A combination of the direct- and indirect-acting antivirals (BC-11 and AHN 1-055) demonstrated better viral entry inhibition than either compound alone.

物理化学性质&存储条件

分子量	210.058
分子式	C8H11BN2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-((carbamimidoylthio)methyl)phenyl)boronic acid

参考文献

1. Moumbock AFA, et al. Arch Pharm (Weinheim). 2022 Oct 31:e2200371.