TMLB-G9

Chemical Structure : TMLB-G9

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货号: PC-28799Not For Human Use, Lab Use Only.

TMLB-G9 is a potent, high affinity inhibitor of Beta-1,3-glucuronosyltransferase (B3GAT3) with KD of 0.72 uM, exhibits potent antiproliferative activity against Huh7 and Hep3B cells (IC50=0.31-0.36 uM) and broad-spectrum antitumor efficacy.

规格	价格	库存	数量
25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

TMLB-G9 is a potent, high affinity inhibitor of Beta-1,3-glucuronosyltransferase (B3GAT3) with KD of 0.72 uM, exhibits potent antiproliferative activity against Huh7 and Hep3B cells (IC50=0.31-0.36 uM) and broad-spectrum antitumor efficacy.
TMLB-G9 suppresses HCC colony formation, migration, and invasion, while inducing G0/G1 arrest and apoptosis.
TMLB-G9 exhibits superior anti-HCC activity to TMLB-C16 in two HCC xenograft models.

物理化学性质&存储条件

分子量	590.59
分子式	C33H26N4O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl 3-(2-((2-(2-(Benzofuran-2-yl)-6-methoxyquinoline-4-carboxamido)ethyl)amino)-2-oxoacetyl)-1H-indole-5-carboxylate

参考文献

1. Hao Yin, et al. J Med Chem. 2026 Sep 24;69(18):21440-21482.

TMLB-G9

生物&药学活性

物理化学性质&存储条件

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TMLB-G9

生物&药学活性

物理化学性质&存储条件

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